Table 5 Initial OPTICC-funded projects, their stage, optimization goals, and use of OPTICC methods

Implementation study 1: ProCRCScreen: increasing colorectal cancer screening in FQHCs through optimized implementation of an evidence-based colorectal cancer screening intervention

1. Examine impact of ProCRCScreen implementation on CRS screening completion

2. Optimize practice facilitation impact on CRC screening rates though feedback on baseline determinants and strategy-determinant alignment

I: Rapid Evidence Reviews, Rapid Ethnography, Design Probes, Determinant Prioritization

II: CPDs

III: Factorial Design

- Maximize the efficiency of practice facilitation using OPTICC methods to conduct a baseline determinant assessment.

- Maximize the impact of practice facilitation by providing feedback on strategy-determinant alignment.

Implementation study 2: Patient-centered Approach to Tailoring HPV self-sampling for cervical cancer screening (PATH)

1. Develop patient-centered outreach materials addressing uptake determinants to increase home HPV testing

2. Determine if the screening outreach strategy needs to be tailored

II: CPDs

III: Efficient Prototyping, Factorial Design

- Maximize patient preference for outreach materials.

- Maximize reach of home HPV testing through tailoring outreach materials.

Pilot study 1: developing a ride-share intervention to improve follow-up of abnormal fecal immunochemical test (FIT) results

1. Determine critical components of a ride-share program in settings where procedural sedation is administered

2. Assess the acceptability, appropriateness, and feasibility of two ride-share models

III: Efficient Prototyping, RAM Test for Signal of Acceptability, Feasibility, Appropriateness

- Maximize alignment of ride-share model features with patient and provider preferences.

- Maximize the reach of abnormal FIT follow-up using ridesharing.

Pilot study 2: a staged approach to implementing hereditary cancer risk assessment (HCRA)

1. Match implementation strategies to determinants to delivery of genetic testing

2. Evaluate a stakeholder-driven approach to HRCA implementation planning

I: Rapid Evidence Review, Determinant Prioritization

II: CPDs

- Maximize impact of HCRA implementation by supporting stakeholders in matching strategies to local determinants.