Table 2 Study outcomes for the evidence-based intervention
Implementation science terminology | Definition | Study terminology | ||
Evidence-based intervention | Evidence-based interventions are supported by research that has established a causal relationship between the intervention and a specified improvement in individual- or population-level health behaviors, health outcomes, or health-related environments [20]. | Evidence-based chemotherapy for advanced-stage Kaposi’s sarcoma | ||
Primary implementation outcomes - intervention | ||||
Implementation science terminology | Definition | Study terminology | Level of evaluation | Outcome measures |
Service Penetration | The number of eligible persons who use a service, divided by the total number of persons eligible for the service [19]. | Chemotherapy initiation | Individual level (person with KS) | Cumulative incidence of receiving the first dose of chemotherapy after KS diagnosis accounting for death as a competing event. |
Fidelity | The degree to which an intervention was implemented as it was prescribed in the original protocol or as it was intended by the program developers [19]. | Chemotherapy completion | Individual level (person with KS) | Cumulative incidence of chemotherapy completion, defined as completing >6 cycles of chemotherapy, completing all cycles recommended by the provider (occasionally <6), or the person with KS completing the prescribed number of cycles up until a provider-driven regimen change, accounting for death as a competing event. |
Secondary service outcomes—intervention | ||||
Timeliness | The reduction of waits and harmful delays for both those who receive and those who give care [21]. | Time to oncology consultation | Individual level (person with KS) | Time in days from when the biopsy result is given to the person with KS to the first oncology consultation |
Secondary client and health outcomes—intervention | ||||
Mortality | Individual level (person with KS) | Cumulative incidence of death | ||
Quality of Life | Individual level (person with KS) | Total Score Quality of Life (Medical Outcomes Study HIV Health Study) [22] | ||
Stigma | Individual level (person with KS) | Total Score Stigma (Abridged Berger HIV Stigma Scale) [23] | ||
Social Support | Individual level (person with KS) | Total Score Social Support (MSPSS) [22] | ||