From: Evaluating blinatumomab implementation in low- and middle-income countries: a study protocol
Research question | Data source |
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(1) Can blinatumomab be adapted for LMIC settings, and is it feasible, acceptable, and appropriate? | 1) Implementation outcomes assessments (FIM, AIM, IAM, cost) 2) Semi-structured interviews 3) Program evaluation group interview |
(2) Does an adapted multidisciplinary training program improve these implementation outcomes? | 1) Knowledge assessments 2) Implementation outcomes assessments (FIM, AIM, IAM, cost) |
(3) Are there contextual factors (readiness, capacity, perceived complexity) that correlate with successful implementation? | 1) Hospital assessment questionnaire 2) Barrier assessments: complexity assessment, ICS, ORIC 3) Implementation outcomes assessments (FIM, AIM, IAM) 4) Semi-structured interviews |
(4) What are the key strategies as perceived by stakeholder groups and are these the same between different groups? | 1) Implementation strategy feedback 2) Program evaluation group interview |
(5) What is stakeholder satisfaction with this implementation-guided approach? | 1) Semi-structured interviews with implementation teams 2) Program evaluation group interview |
(6) Is the effectiveness of this adapted administration of blinatumomab the same as what has been documented in high-income settings? | 1) Patient enrollment information 2) Patient safety record: adverse event reporting 3) Management records: interruption record 4) Clinical outcome data |