Author, year | Study location | Population characteristics | Study design | Sample size | Intervention description | Outcomes measures | Results |
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Gizaw et al., 2019 [47] | Ethiopia | Women Age: 30–49 years | CRCT | 1299 (HPV Self-sampling arm:835; VIA arm:464) | Intervention: One arm of the intervention involved self-collection-based HPV DNA testing. Women were offered an Evalyn Brush (Rovers) to collect a swab under active supervision by a trained health professional. Women collected samples in a private area in the health post. Samples were immediately placed in a plastic bag provided by the Evalyn Brush Company after giving a unique ID to the study participants. Control: The other arm of the study completed VIA at a hospital. A trained and certified the nurse was responsible for performing the screening. All women who tested VIA positive were rescreened by a gynecologist for quality assurance. | Uptake of HPV testing | Of those women who attended the VIA and HPV arms, 40%, and 65.4% adhered to all procedures expected after the screening, respectively. Out of women positive for high-risk HPV, 122 (85%) attended VIA as a follow-up test. The trial demonstrated significantly higher levels of population-based uptake and adherence for self-collection HPV testing. |
Huchko et al., 2017 [46]; Oketch et al., 2019 [80]; Page et al., 2019 [81] | Kenya | Women Age: 25–65 years | CRCT | 4944 | Intervention: Cervical cancer screening was carried out using HPV testing of self-collected specimens through community health campaigns Device-careHPV Control: HPV testing at health facilities | Uptake of HPV testing | Screening uptake was greater in communities assigned to community health campaigns compared to those assigned to receive screening through health facilities (60.0% vs 37.0%, P<0.001). |
Modibbo et al., 2017 [48] | Nigeria | Women residing in an urban area Age: 30–65 years | RCT | 400 (Intervention group: 200; Control group: 200) | Intervention: HPV self-sampling kit directly mailed to the home address with a prepaid return envelope (or could drop off the completed kit at designated collection points in the community or the hospital). Cervicovaginal specimen, collected at home, unsupervised. Device: Not reported Control: HPV testing appointment at the hospital clinic. | Uptake of HPV testing services Length of follow-up: 1 month | Most participants in the self-collection arm (93%, 185/200) submitted their samples while only 56% (113/200) of those invited to the hospital for sample collection attended and were screened during the study period (p value < 0.001). |
Moses et al., 2015 [49]; Mezei et al., 2018 [10] | Uganda | Women residing in an urban area Age: 30–65 years | RCT | 500 (Intervention group:250; Control group: 250) | Intervention: HPV self-sampling kit and education offered door-to-door by outreach worker (return to the worker). Cervicovaginal specimen, collected at home, unsupervised. Device: Dacron swab. Control: Screened by a healthcare provider (VIA) | Uptake of HPV testing services. Linkage to clinical assessment or HPV treatment | In the HR-HPV arm, 248 of 250 (p < 0.01) women provided samples, while in the VIA arm, 121 of 250 (48.4%) women attended the screening. Among the 73 of 248 HR-HPV-positive women, 45.2% (N = 33) attended VIA screening for follow-up, 21.2% (N = 7) of whom screened positive; five received treatment, and two were missing clinical follow-up records. Of the 121 women in the VIA arm who attended the screening, 13.2% (N = 16) screened positive; seven received cryotherapy, three refused treatment, five were referred to colposcopy; and one woman had suspected cervical cancer and received treatment after confirmatory testing. |
Sossauer et al., 2014 [45] | Cameroon | Women Age: 25–65 years | RCT | 301 (Intervention group:152; Control group: 149) | Intervention: Standard information (this included explanations about what the tests detects (HPV), the link between HPV and cervical cancer, and how to perform HPV self-sampling) followed by the educational intervention (this consisted of a culturally tailored video about HPV, cervical cancer, Self-HPV, and its relevancy as a screening test). Control: Standard information | Knowledge about HPV and acceptability and confidence in using self-HPV | 301 women (149 in the “control group” and 152 in the “intervention group”) completed the full process and were included in the analysis. Participants who received the educational intervention had a significantly higher knowledge about HPV and cervical cancer than the control group (p,0.05), but no significant difference in Self-HPV acceptability and confidence in the method was noticed between the two groups. |