Systems Analysis and Improvement Approach to optimize the pediatric and adolescent HIV Cascade (SAIA-PEDS): a pilot study

Wagner, Anjuli D.; Augusto, Orvalho; Njuguna, Irene N.; Gaitho, Douglas; Mburu, Nancy; Oluoch, Geoffrey; Carimo, Naziat; Mwaura, Peter; Cherutich, Peter; Oyiengo, Laura; Gimbel, Sarah; John-Stewart, Grace C.; Nduati, Ruth; Sherr, Kenneth

doi:10.1186/s43058-022-00272-8

Implementation Science Communications

Table 1 Regression analyses using pre-post model and interrupted time series

From: Systems Analysis and Improvement Approach to optimize the pediatric and adolescent HIV Cascade (SAIA-PEDS): a pilot study

		Baseline average monthly volumes across 5 clinics^	Pre-post model		Interrupted time series model
			Pre-post model		Baseline temporal trend		Step change		Slope change
			RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI
Uptake of HIV testing	Numerator	253	1.449	[0.627, 3.347]	1.118	[0.959, 1.305]	1.154	[0.731, 1.823]	0.846**	[0.750, 0.955]
	Denominator	842	1.819***	[1.346, 2.457]	1.121**	[1.038, 1.210]	1.077	[0.759, 1.527]	0.932	[0.849, 1.023]
	Ratio	--	0.803	[0.420, 1.532]	0.998	[0.860, 1.158]	1.079	[0.645, 1.807]	0.905	[0.788, 1.039]
Linkage to HIV care	Numerator	6	0.841	[0.621, 1.139]	0.973	[0.859, 1.102]	0.890	[0.485, 1.633]	1.044	[0.882, 1.236]
	Denominator	6	1.055	[0.659, 1.691]	0.933	[0.809, 1.076]	1.589	[0.849, 2.974]	1.013	[0.859, 1.196]
	Ratio	--	0.831	[0.546, 1.266]	1.042	[0.880, 1.235]	0.549	[0.246, 1.224]	1.057	[0.844, 1.325]
ART initiation	Numerator	5	1.264	[0.850, 1.880]	0.992	[0.852, 1.156]	1.302	[0.668, 2.540]	0.981	[0.818, 1.176]
	Denominator	6	0.841	[0.621, 1.139]	0.973	[0.859, 1.102]	0.890	[0.485, 1.633]	1.044	[0.882, 1.236]
	Ratio	--	1.412	[0.999, 1.996]	0.990	[0.854, 1.148]	1.556	[0.773, 3.131]	0.987	[0.814, 1.198]
VL order	Numerator	15	1.896***	[1.366, 2.633]	1.093	[0.949, 1.259]	1.792	[0.940, 3.419]	0.845	[0.709, 1.007]
	Excluding extreme clinic	20	1.469*	[1.073, 2.010]	1.170*	[1.035, 1.323]	1.291	[0.743, 2.244]	0.752***	[0.646, 0.876]
	Ratio	--	1.939**	[1.230, 3.055]	1.074	[0.908, 1.271]	1.810	[0.850, 3.855]	0.886	[0.720, 1.090]
	Excluding extreme clinic	--	1.408	[0.981, 2.021]	1.171*	[1.010, 1.358]	1.168	[0.613, 2.229]	0.770**	[0.643, 0.923]
VL suppressed	Numerator	13	1.595**	[1.189, 2.140]	1.099	[0.967, 1.249]	1.214	[0.676, 2.180]	0.899	[0.766, 1.054]
	Excluding extreme clinic	13	1.642**	[1.174, 2.298]	1.092	[0.942, 1.265]	1.379	[0.709, 2.682]	0.883	[0.736, 1.060]
	Denominator	15	1.896***	[1.366, 2.633]	1.093	[0.949, 1.259]	1.792	[0.940, 3.419]	0.845	[0.709, 1.007]
	Excluding extreme clinic	20	1.469*	[1.073, 2.010]	1.170*	[1.035, 1.323]	1.291	[0.743, 2.244]	0.752***	[0.646, 0.876]
	Ratio	--	0.851	[0.554, 1.306]	1.005	[0.892, 1.132]	0.677	[0.392, 1.169]	1.064	[0.917, 1.234]
	Excluding extreme clinic	--	1.119	[0.880, 1.422]	0.934	[0.846, 1.032]	1.065	[0.678, 1.674]	1.172*	[1.036, 1.325]

*p < 0.05, **p < 0.01, ***p < 0.001
^Modeled values represent geometric means across 5 facilities derived from linear mixed-effects models utilizing log transformed values

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