Table 1 Summary of implementation aims
Aim | Quantitative analyses | Qualitative analyses | ||
|---|---|---|---|---|
Analysis unit and method | Primary predictors | Outcomes (RE-AIM) | ||
Aim 1: Monitor participation in In Our DNA SC, identify, and assess factors associated with participant engagement | Analysis unit: Individual Analysis method: All outcomes assessed cross-sectional (weekly reports to leadership) and longitudinally | Demographics: • Age • Sex • Race • Ethnicity Collection site | Reach: • # of eligible individuals reached • # viewed recruitment message • # declined • # non-response • # expressed interest • # enrolled Implementation: Among those enrolled in In Our DNA SC: • # of samples collected • # Re-collected • # Results sent • Timeliness of return of results Effectiveness/efficacy: • Number of people who complete In Our DNA SC • Positive patients who follow-up with genetic counselor Maintenance: • High-risk management of positive patients (number of people visiting genetic counselor who schedule screening) | Participant interviews • Efficacy: Participant experiences and satisfaction with the program • Rapid analysis initially to provide necessary information • Full, in-depth coding using thematic analysis approach • Participants stratified based on the type of engagement (declined, non-response, enrolled) |
Aim 2: Assess contextual factors and strategies that may influence adoption and sustainment of In Our DNA SC among clinical and community sites and ongoing site-specific needs related to program implementation | Analysis unit: Site Analysis method: Bivariate analyses and multivariable linear regression to assess influence of predictors on adoption and maintenance | Use of training materials Use of community-facing education materials Implementation site logs (number and type of facilitators and barriers identified) Research coordinator logs (number and type of question) Site readiness survey (AIM, IAM, FIM) | Adoption: • Total number of MUSC and community sites enrolling • Differences in adoption across SC Maintenance: Sites that In Our DNA SC is continued | Implementation Site Logs: Rapid deductive qualtiative analysis |
Aim 3: Describe facilitators and barriers to implementation and perceptions of In Our DNA SC among work group members | Analysis unit: Work group, implementation team Analysis method: Frequency and percent, mean and standard deviation; cross-sectional and longitudinal | Work group logs: Summarize implementation barriers and facilitators by work group and over time Check-in survey: Summarize perception of program by work group and over time | Work Group Logs: Rapid deductive qualitative analysis | |
Aim 4: Track adaptations made to In Our DNA SC to assess how mechanisms of change impact key programmatic outcomes | Analysis unit: Program Analysis method: Summary of type of adaptations made | Implementation: • Number and type of adaptations made to program over time | All RE-AIM outcomes and whether positive, negative, or no impact | N/A |