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Table 2 Integration of research methods, implementation science (IS) frameworks, and implementation strategies by INSPIRE phase

From: Implementation of new technologies designed to improve cervical cancer screening and completion of care in low-resource settings: a case study from the Proyecto Precancer

 

INSPIRE ACTION

RESEARCH METHODS UTILIZED

IS FRAMEWORKS

IMPLEMENTATION STRATEGIES

INSPIRE HUB

1. Define problem situation with stakeholders

Soft systems methodology

CFIR Domain 1: intervention source

Build buy-in (involve existing governance structures, ID champions)

Develop relationships (build coalitions, resource-sharing agreements, formal commitments, academic partnerships)

CFIR Domain 5: engaging

2. Launch the project

PHASE 1: UNDERSTAND THE SYSTEM

3. Developmental models of the system

AIIM

SAST stage 1 with key informant interviews and focus group discussions

KAP surveys

Audits of current system outcomes

Pathway analysis visually represented by flow charts and swim-lane diagrams

CFIR Domain 3: defining structural characteristics, networks, & communications

Gather information (needs assessment, readiness to change)

Involve patient/consumers and family members

4. Establish narrative and stakeholder perceptions of the system

CFIR Domain 2: culture & implementation climate

Audit current system behavior

Capture and share local knowledge

CFIR Domain 3: patient needs and resources

CFIR Domain 3: external policies & incentives

CFIR Domain 4: knowledge & beliefs about the intervention

CFIR Domain 4: understand self-efficacy, individual stage of change and other attributes

5. Make the system visible

PHASE 2: FIND LEVERAGE

6. Engage stakeholders in group model building

SAST Stage 2 – design workshops

Dialectic debate and group model building (facilitated with goal to balance desirability and feasibility guided by reflection on implementation outcomes such as feasibility, cost, acceptability, sustainability, etc.)

Scenario analysis

CFIR Domain 1: review characteristics of the intervention and options (evidence strength and quality, relative advantage, complexity, cost) & assess adaptability and trialability of alternatives

CFIR Domain 3: assess cosmopolitanism, peer pressure, influence of external policies/incentives

CFIR Domain 4: assess KAB about intervention options

CFIR Domain 4: Group level stage of change

Assess readiness and identify barriers

Get feedback from audit of current system behavior

Purposefully re-examine the intervention

Tailor strategies to overcome barriers and honor preferences

Model and simulate change

Conduct local consensus discussions

Distribute educational materials and conduct educational meetings

Make training/education dynamic and participatory

Inform local opinion leaders

Create a learning collaborative

Consider restructuring strategies as leverage opportunities

Consider financing strategies as leverage opportunities

Mandate change

7. Share, test, revise system/process maps

8. Define and localize system behaviors contributing to problem situation

9. Find leverage for change

PHASE 3: ACT STRATEGICALLY

10. Stakeholder designed implementation plan

11. Infrastructure modifications, training, dissemination plan development

12. Implement changes

Work group soft systems methodology with research team facilitation

CFIR Domain 1: design quality

CFIR Domain 1: complexity

CFIR Domain 5: planning

CFIR Domain 5: executing

Develop a formal implementation blueprint

Tailor strategies to overcome barriers and honor preferences

Stage implementation scale-up

Involve patients/consumers and family members

Recruit, designate, and train for leadership

Obtain formal commitments

Develop effective educational materials relevant to mandated change

Develop a glossary of implementation (including new models)

Distribute educational materials

Conduct ongoing, dynamic training

Conduct educational outreach visits

Use train-the-trainer strategies

Provide ongoing consultation

Place new interventions on fee for service lists/formularies

Develop supply chain management

Revise professional roles

Create new clinical teams

Change services sites

Change equipment

Change records systems

Develop and organize quality monitoring systems

Develop tools for quality monitoring

Use advisory boards and work groups

Conduct cyclical tests of change

Create or change credentialing and/or licensure standards

PHASE 4: LEARN AND ADAPT

13. Ongoing M&E using stakeholder defined implementation outcome metrics

14. Share M&E with stakeholder group

15. Re-initiate INSPIRE cycle where indicated by identification and localization of new or unresolved problem situation

M&E for primary implementation outcomes

SAST with KII and FGD

Design workshops

RE-AIM

CFIR Domain 5: Reflecting and evaluating

Provide ongoing consultation

Sustain a learning collaborative

Use mass media to increase reach (only after system behavior is stabilized post-implementation)

Use advisory boards and working groups

Organize clinical implementation team meetings

  1. Reproduced from Cancer Epidemiology, Biomarkers & Prevention. 2020. Vol.29,9, 1710–1719, Gravitt, P. et al., “Integrative Systems Praxis for Implementation Research (INSPIRE): An Implementation Methodology to Facilitate the Global Elimination of Cervical Cancer., with permission from the American Association for Cancer Research (AACR)
  2. Abbreviations: AIIM, alignment, influence, and interest matrix; CFIR, Consolidated Framework for Implementation Research; DW, design workshop; FGD, focus group discussions; HSF, health systems framework; ID: Infectious Disease; KAB, knowledge attitudes and beliefs; KAP, knowledge, attitudes, and practices; KII, key informant interview; SAST, strategic assumption surfacing and testing