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Barriers and facilitators affecting implementation of the Canadian clinical practice guidelines for the diagnosis of acute aortic syndrome

Abstract

Background

Acute aortic syndrome (AAS) is an uncommon, life-threatening emergency that is frequently misdiagnosed. The 2020 Canadian clinical practice guidelines for the diagnosis of AAS incorporate all available evidence into four key recommendations. In order to facilitate the implementation of these recommendations, a clinical decision aid was created. The objective of this study was to identify barriers and facilitators among physicians prior to implementation of the guideline recommendations in a multicentre step wedge cluster randomized control trial.

Methods

We conducted semi-structured interviews with nine emergency room physicians working at five sites distributed between urban academic and rural settings. We used purposive sampling, contacting physicians until data saturation was reached. Interview questions were designed to understand potential barriers and facilitators to guideline recommendation uptake and use. Responses were analysed according to the Theoretical Domains Framework, and overarching themes describing these barriers and facilitators were identified.

Results

Two themes and six subthemes encompassing 13 theoretical domains were identified. These included clinical decision-making support, awareness of the evidence, social factors, expected consequences, ability of physicians to acquire the necessary data and ease of use. A majority of interviewees anticipated that the guideline recommendations would support clinical decision making and more effectively risk-stratify patients. Other facilitators included endorsement of the guidelines by professional organizations and peers. Barriers to implementation include the fact that laboratory testing and knowledge of the rationale for its use in the investigation of AAS were not widespread. The complexity of the clinical decision aid and concerns about test specificity were also identified as potential barriers to use.

Conclusion

Physicians were amenable to using the AAS guideline recommendations to support clinical decision-making and to reduce resource use. A structured intervention should be developed to address the identified barriers and leverage the facilitators in order to ensure successful implementation. Our findings may have implications for the implementation of other guidelines used in emergency departments.

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Background

Acute aortic syndrome (AAS) refers to a group of life-threatening aortic pathologies including aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer. This uncommon but potentially lethal condition is challenging to diagnose [1]. The low incidence of AAS, varied presenting symptoms, and lack of a standard diagnostic pathway has led to a misdiagnosis rate as high as 38% [2,3,4].

In order to address these challenges, Ohle et al. developed clinical practice guidelines for the diagnosis of AAS [5]. The guidelines incorporate all available evidence for the historical risk factors, patient symptoms, and physical exam findings associated with AAS into a clinical decision aid for risk stratification (see Additional file 1). Patients found to be at low risk require no further investigation for AAS, while those having a moderate pre-test probability can be further risk-stratified using a biochemical assay, the D-dimer test [6]. It is recommended that patients determined to be at high risk (corresponding to a pre-test probability of AAS greater than 5%) receive urgent imaging. The purpose of the guideline recommendations is to support clinical decision making in cases of suspected AAS, thereby minimizing diagnostic delays, misdiagnoses, and unnecessary advanced imaging.

Clinical guidelines are developed with the intention of standardizing clinicians’ approach to the diagnosis and treatment of disease, thereby improving patient outcomes and reducing resource overuse. However, they are only useful if incorporated into practice. The success of guideline implementation can be improved if the intervention addresses barriers and promotes behaviours or attitudes that will facilitate uptake. Interviewing end-users regarding the barriers and facilitators to guideline implementation is increasingly recognized as a crucial part of implementation planning and has been used to inform and evaluate strategies for maximizing the uptake of guidelines and clinical decision aids [7, 8]. The Theoretical Domains Framework (TDF) is a validated, integrative framework based on behavioural change theory that can be used to identify barriers and facilitators to behavioural change across 14 domains covering 84 theoretical constructs [9,10,11]. Data generated using this approach can be used to inform the design of implementation strategies that maximize the uptake of and adherence to both new and existing guidelines in the emergency department and beyond [8, 12,13,14,15].

In this paper, we report on the barriers and facilitators to the implementation of the new AAS clinical practice guidelines perceived by emergency physicians. Using the theoretical domains framework to guide our analysis of physician responses allows the barriers to be linked to the specific interventions most likely to facilitate guideline uptake and use [16, 17]. Adherence to clinical practice guidelines in this setting varies widely, but tailored interventions that address prospectively identified barriers may improve rates of adherence in a coming multicentre study [18,19,20].

Methods

This study is part of a larger 10 site step wedge cluster randomized control trial for the implementation of the Canadian clinical practice guidelines for the diagnosis of AAS. A mixed deductive and inductive approach was taken to the analysis [21]. The initial data analysis involved a deductive content analysis in which utterances were coded into TDF domains. A subsequent inductive thematic analysis identified overarching themes that emerged among throughout the process of coding statements into TDF domains [22].

Participants and setting

Participants were a purposive sample of practicing emergency room physicians from three academic centers and two rural emergency departments in Ontario (Table 1). These sites were a representative sample of the 10 planned implementation sites. Participants were recruited from each site by emailing emergency physicians at each site and inviting them to participate in a telephone interview. Based on prior studies, a predicted sample size of 8–12 participants was estimated, and interviews continued until no new themes had emerged for two consecutive interviews [7, 13, 14].

Table 1 Demographic information of ER physicians interviewed

Interview procedure

Interviews were conducted by CD, a research assistant with no personal relationship to the participants, using a semi-structured approach (Additional file 2). Interviews took place between July and October 2019 and were audio recorded, transcribed verbatim and anonymized. The interview began with a detailed review of the decision aid and was followed by a series of open-ended questions designed to elicit the thoughts, beliefs and opinions regarding barriers and facilitators to implementing the guideline recommendations.

Data analysis

The authors had not previously conducted studies applying the TDF and followed the guidance of Atkins et al. [10]. The first interview was coded collaboratively by the authors in order to establish a shared understanding of TDF domains and their definitions and to develop the initial coding guideline [9, 10]. Throughout the coding process, coding criteria were continuously reviewed and refined as described in the final coding guideline (Additional file 3). Subsequent interviews were coded independently in order to support trustworthiness of coding. When discrepancies in coding arose, they were resolved through discussion.

Coded utterances were then grouped into belief statements that represented similar responses across interviewees. Belief statements were generated by one reviewer (CD) and verified by another (RO), and supporting verbatim quotes are provided. Frequencies for each belief statement were compiled with each one being counted only once per interview. Thematic analysis of the belief statements generated from the TDF analysis was conducted according to the process outlined by Braun and Clarke [22].

Results

Nine semi-structured interviews were conducted with practicing ER physicians (Table 1).

One hundred twenty-two utterances were coded into the 14 TDF domains, thirteen of which were identified as potentially influencing guideline recommendation uptake and accurate use. No utterances were coded into the domain Intention, as all physicians expressed some degree of interest in adopting the guideline recommendations. A variety of rationales were given for the stated intention to adopt or delay adopting the aid, and these were coded to the domain that best captured the specific reasoning. Belief statements generated from these utterances described barriers and facilitators to implementation (Table 2) and accurate application (Table 3) of the guideline recommendations. Within this data, two overarching themes encompassing six sub-themes were identified.

Table 2 Domains describing barriers and facilitators to decision aid implementation
Table 3 Domains describing barriers and facilitators to accurate application of decision aid

I. Barriers and facilitators to implementation of the guideline recommendations

a. Decision-making support

Relevant TDF domains: beliefs about capability, emotion, goals, optimism, social influences, social/professional role and identity

Interviewees were largely receptive to the development of a clinical practice guideline for AAS. The reasons included a belief that the guideline recommendations were likely to reduce the number of missed cases of AAS, in part by forcing clinicians to consider the diagnosis more often, and the potential for D-dimer to safely reduce imaging rates by effectively risk-stratifying them prior to CT. Other perceived benefits of evidence-based guideline recommendations included reducing clinician anxiety, justifying clinical decisions (such as imaging orders) to colleagues, and aiding in shared decision making with patients.

The relative advantage of evidence-based guideline recommendations over clinical gestalt was controversial, with some physicians stating their conviction that guidelines are preferable, particularly for less experienced clinicians. Others expressed the belief that clinical gestalt is generally superior to guidelines, or that such tools are best used to supplement or guide clinical decision making rather than replacing it.

“I think a lot of times too with these decision aids… it gets shown that clinical gestalt and experience is worth just as much.” (Emergency Physician 8)

b) Awareness of the evidence

Relevant TDF domains: knowledge; behavioural regulation

A major theme was whether scoring criteria and follow-up investigation aligned or did not align with individual practice or understanding of the evidence. Of particular concern was the use of D-dimer as a screening tool in AAS. Several physicians were previously unaware of its potential application in AAS, and the majority of respondents expressed concern that the test was insufficiently specific given the variety of factors independent of AAS that may cause D-dimer to be elevated. Three respondents suggested that validation studies demonstrating the adequacy of D-dimer sensitivity and specificity in AAS were pre-requisites to adopting the guidelines into practice.

c) Social influences on the probability of adopting the guideline recommendations

Relevant TDF domains: social influences

Respondents were more likely to follow the guideline recommendations if it were published in a high-quality, peer-reviewed journal and endorsed by professional organizations representing medical specialties involved in the treatment of AAS. Uptake of the guidelines by departmental colleagues was also considered to be an important motivating factor.

d) Consequences of guideline use

Relevant TDF domains: beliefs about consequences, optimism, reinforcement, environmental context and resources

Many physicians felt that the guidelines were likely to increase the number of D-dimers ordered and lead to higher rates of CT scanning. Conversely, for physicians practicing in rural settings, the use of D-dimer screening was seen as a potential means for reducing patient transports to obtain imaging, which given the loss of accompanying ER staff, significantly strains rural emergency department capacity and workflow.

II. Barriers and facilitators to accurate application of the guideline recommendations

a. Ability to acquire required necessary data

Relevant TDF domains: skill; environmental context and resources

Respondents expressed concern about their own ability or that of others to assess the physical exam findings used to risk-stratify patients, noting that variable proficiency in the use of point of care ultrasound among practitioners was likely to impact their ability to follow the guideline recommendations.

“What I don't have is this clinical skill, and I don't think probably anybody in our department has the ability…to measure aortic regurgitation or insufficiency.” (Emergency Physician 1)

Incomplete patient histories might similarly limit scoring accuracy; for example, patients may be unaware of the existence or nature of a pre-existing heart murmur or aortic valve disease.

Processing times for D-dimer varied among institutions, which influenced the probability of following the guideline recommendations accordingly. Some physicians were concerned that delays in D-dimer results were such that they might not wait to order a CT. On the other hand, at two rural facilities point of care D-dimer results were available immediately, such that clinicians viewed this step as a means of accelerating care for patients at risk of AAS.

b. Ease of use

Relevant TDF domains: knowledge, memory, attention and decision processes; beliefs about capabilities, beliefs about consequences

Physicians were divided in their response to the complexity of the guideline recommendations. Some reported that they found the clinical decision aid straightforward and easy to use. Other commented that the decision aid was too long to memorize, and several respondents suggested that a mobile app would be instrumental in promoting its use.

“I don't think this is a tool you can memorize.” (Emergency Physician 4)

Two physicians emphasized the importance of featuring inclusion criteria prominently at the top of the clinical decision aid, noting that this was a barrier to the correct use of existing decision aids. Finally, there was concern that subjectivity within the decision aid (specifically with regard to pain severity and probability of alternate diagnosis) was likely to increase scores and promote unnecessary testing.

Discussion

In this study, we identified the barriers and facilitators likely to influence the implementation of the Canadian practice guideline for the diagnosis of AAS, with the goal of informing our intervention strategies for a multicentre implementation trial. Our findings also have broader implications for the design and uptake of guideline recommendations and decision aids in emergency departments in general.

Emergency physicians are required to make complex, cognitively challenging decisions regarding diagnostic assessment and management of patients in a crowded, time-constrained environment [23]. The development of clinical practice guidelines and decision aids is aimed at reducing practice variation and improving patient outcomes, while simultaneously minimizing unnecessary and potentially harmful testing.

Overall, physicians responded positively to the development of a guideline for the diagnosis of AAS because of the catastrophic nature of the condition and the diagnostic challenge it presents. The central barriers identified included factors that limited clinician capability (the capacity to adopt and use the guideline recommendations, including sufficient knowledge and skill) and motivation to adopt the guideline in light of concerns about its complexity and the specificity of D-dimer in the investigation of AAS.

Implications for the implementation of guideline recommendations

The guideline recommendations were seen as having the potential to improve risk stratification of patients being investigated for AAS. Although designed specifically to inform clinical decision making by emergency physicians, this finding underscores the potential of the decision aid to support shared decision making with both colleagues and patients. Patients may thus derive additional benefits from the decision rule, including improved knowledge and a closer correspondence between their values and decisions [24].

Knowledge of the scientific rationale and pre-implementation skills training have repeatedly been cited as enablers to implementation of new guidelines and decision aids in the ED and other contexts [7, 12, 25]. Effective dissemination of the evidence underlying the decision aid is crucial, and respondents in the present study identified validation and publication of the guidelines in high quality journals as pre-requisites to uptake, as has previously been shown [17]. These challenges can be addressed by offering thorough pre-implementation training, continuing medical education credits and by providing a supporting appraisal of the evidence alongside the decision aid [26].

While physicians were confident about the likely sensitivity of the clinical decision aid, there was near universal concern that imaging could increase as a result of low specificity, impeding workflow and exposing patients to unnecessary radiation. Thus, in addition to validation studies investigating sensitivity and specificity of the clinical decision aid, the effect of the decision aid on imaging orders should also be assessed. The complexity of the decision aid was also perceived to be a barrier to use, particularly in a busy emergency department. Indeed, studies of other decision aids have shown that they are often used incorrectly in practice, being applied in patients that do not meet inclusion criteria used in validation studies or adding steps that were not included in the validated decision aid [7, 27, 28]. Evidence suggests that even relatively simple decision rules in common practice are difficult to remember [27]. The planned intervention must therefore incorporate a visually simple decision aid in which inclusion criteria are clearly presented at the outset. Environmental restructuring, such as facilitated access to copies of the clinical decision aid, an app, or integrating it into the electronic medical record, is also likely to support practice change.

Strengths and limitations

The strengths of this study included the use of a theoretical framework to guide analysis of interview responses. Interviewees were selected from multiple institutions and represented diverse levels of experience and demographics in both urban and rural settings.

The limitations of the study included a relatively small sample size, though we ensured thematic saturation was reached by conducting two additional interviews after no new themes emerged. Interview questions were not designed to address specific theoretical domains, which may cause certain domains to be underrepresented in the data if they did not arise spontaneously. However, our approach increased the chances of identifying those barriers and facilitators that were the most salient to emergency physicians. Finally, given that the investigation was conducted prior to decision aid distribution and implementation, it is possible that unforeseen barriers will arise despite the attempt to address them a priori.

Conclusions

Physicians were amenable to using the AAS decision aid due to its potential to support clinical decision-making and reduce resource utilization in a difficult to diagnose and lethal condition. Key barriers identified included the need for additional education and training prior to implementation of the guideline recommendations and concern about specificity of the decision aid criteria and D-dimer. Addressing these barriers pre-implementation through training, education and thoughtful design of the decision aid may improve integration of guideline recommendations into practice.

Availability of data and materials

All data generated or analysed during this study are included in this published article and its supplementary information files.

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Acknowledgements

We thank Clare Cook for comments on a previous version of the manuscript.

Funding

CD received a student research grant from the Mach-Gaensslen Foundation of Canada.

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Contributions

CD was responsible for analysis and manuscript preparation. RO was responsible for study design, analysis, oversight, and manuscript editing. The authors read and approved the final manuscript.

Corresponding author

Correspondence to Robert Ohle.

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The Health Sciences North Research Ethics board approved this research. All participants provided their informed consent to participate.

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Supplementary Information

Additional file 1.

Acute aortic syndrome risk score.

Additional file 2.

Interview script.

Additional file 3.

Final coding manual.

Additional file 4.

SRQR Checklist.

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Dmitriew, C., Ohle, R. Barriers and facilitators affecting implementation of the Canadian clinical practice guidelines for the diagnosis of acute aortic syndrome. Implement Sci Commun 2, 60 (2021). https://doi.org/10.1186/s43058-021-00160-7

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Keywords

  • Aortic dissection
  • Theoretical domains framework
  • Emergency medicine