Skip to main content

Healthcare worker perceived barriers and facilitators to implementing a tuberculosis preventive therapy program in rural South Africa: a content analysis using the consolidated framework for implementation research



South African national tuberculosis (TB) guidelines, in accordance with the World Health Organization, recommend conducting routine household TB contact investigation with provision of TB preventive therapy (TPT) for those who qualify. However, implementation of TPT has been suboptimal in rural South Africa. We sought to identify barriers and facilitators to TB contact investigations and TPT management in rural Eastern Cape, South Africa, to inform the development of an implementation strategy to launch a comprehensive TB program.


We collected qualitative data through individual semi-structured interviews with 19 healthcare workers at a district hospital and four surrounding primary-care clinics referring to the hospital. The consolidated framework for implementation research (CFIR) was used to develop interview questions as well as guide deductive content analysis to determine potential drivers of implementation success or failure.


A total of 19 healthcare workers were interviewed. Identified common barriers included lack of provider knowledge regarding efficacy of TPT, lack of TPT documentation workflows for clinicians, and widespread community resource constraints. Facilitators identified included healthcare workers high interest to learn more about the effectiveness of TPT, interest in problem-solving logistical barriers in provision of comprehensive TB care (including TPT), and desire for clinic and nurse-led TB prevention efforts.


The use of the CFIR, a validated implementation determinants framework, provided a systematic approach to identify barriers and facilitators to TB household contact investigation, specifically the provision and management of TPT in this rural, high TB burden setting. Specific resources—time, trainings, and evidence—are necessary to ensure healthcare providers feel knowledgeable and competent about TPT prior to prescribing it more broadly. Tangible resources such as improved data systems coupled with political coordination and funding for TPT programming are essential for sustainability.

Peer Review reports


To provide tuberculosis preventive therapy (TPT) to high-risk individuals, health systems—and healthcare workers (HCWs)—must effectively screen individuals to rule out disease and, if appropriate, initiate TPT. Systematically screening individuals from high-risk groups is often challenging in low-resource settings. However, once disease is ruled out, TPT is 60–90% effective [1,2,3,4].

Currently, little is known about HCWs knowledge, attitudes, and beliefs regarding TPT to asymptomatic household contacts in low-resource, high TB incidence settings, such as South Africa [5, 6]. Perceptions of HCWs implementing interventions is critical to its success, especially in South Africa where the landscape of TPT guidelines and regimens are quickly evolving [7, 8]. Poor HCW adoption leads to limited maintenance of interventions, making interventions more likely to fail [9]. Therefore, prior to implementing a comprehensive TB program in rural South Africa, the aim of this study was to understand HCWs’ perceived barriers and facilitators on factors influencing TPT provision and drivers of implementation success or failure using the Consolidated Framework for Implementation Science (CFIR).



This study took place in the King Sabata Dalindyebo (KSD) sub-district, Eastern Cape (Fig. 1). The district hospital serves nearly 130,000 people and supports surrounding clinics. Since 2014, TPT has been routinely recommended for people living with HIV and children under five who are household contacts of patients with TB per South African policy [10].

Fig. 1
figure 1

King Sabata Dalindyebo District Municipality

Study design

This was a baseline qualitative study inform the implementation of a forthcoming, comprehensive TB program. The original CFIR was used to guide interview development, prior to dissemination of the updated 2022 CFIR 2.0 [11]. Standards for Reporting Qualitative Research (SRQR) was used to adhere to reporting guidelines [12].

Sampling and recruitment

Purposive sampling was used to recruit HCWs directly involved with the TB program. Participants included doctors, professional and enrolled nurses, radiographers, pharmacists/pharmacy technicians, and TB data managers. All participants were over 18 years (Table 1).

Table 1 Description of participants

Data collection

All interviews took place at the hospital and four referral clinics in April 2021. Data were collected, confidentially in private offices, via individual semi-structured interviews lasting 30 to 60 min. Interview guide included (Supplement 1). Interviews were conducted in English and audio-recorded. Written informed consent was obtained prior to participation. No compensation was provided. Transcription was completed by Lain Transcription and uploaded into Dedoose for coding [13].

Data analysis

A deductive content analytic approach was used to code descriptive quotes identified through analysis. The CFIR codebook, including pre-specified domains and constructs, was used to guide analysis. Illustrative quotes were subsequently mapped onto the CFIR framework (Fig. 2). Data were reviewed and coded by BvdW and MW. To ensure inter-coder reliability, 20% (n = 4) of interviews were double coded. Coders discussed discrepancies until consensus was achieved and coders agreed on to which construct a code (or quote) mapped. Subsequent interviews were coded independently. Coders went through codes, by construct, synthesizing barriers and facilitators to implementation (Tables 2 and 3).

Fig. 2
figure 2

Consolidated framework for implementation research (copyright: CFIR)

Table 2 Barriers to implementing TB preventive therapy into a comprehensive TB program in a rural setting by CFIR domain and construct
Table 3 Facilitators to implementing TB preventive therapy into a comprehensive TB program in a rural setting by CFIR domain and construct

Ethics approval

Ethics approval was obtained from Harvard Medical School, Boston, MA (IRB20-2122), Walter Sisulu University, Mthatha, South Africa (014/2021), and Eastern Cape Department of Health (EC_202104_002).


Nineteen participants were interviewed. Interviewees included ten hospital- and nine clinic-based individuals with a total of eight nurses, six doctors, two radiographers, two pharmacists, and one TB data clerk (Table 1). Ages ranged from 20 years to mid-50 s.

Results by CFIR domains and constructs

Intervention characteristics

Design quality and packaging of the intervention: looking at the “big picture” and patient-centered design

Participants described many topics around design quality and packaging the program well, specifically having innovative, novel interventions reflecting the needs of patients and providers. Quality documentation for TPT also arose. Currently, there are no systems in place to ensure follow-up and treatment for individuals on TPT (Quote Line Number 38, Supplement 2). Conceptualizing a comprehensive data management system that remains simple and algorithmic is important to overall design of the intervention. This system could be incrementally introduced, until the program is functioning at full capacity (Line 49, 52, 54, 55).

Participants also discussed the need for interventions to be patient-centered. First, to increase adherence, some HCWs recommended providing patients with the full length of treatment upon initiation rather than monthly refills (Line 50). Also, having the intervention clinic-based rather than hospital-based was suggested as improving success. This would improve feasibility and sustainability as clinics are embedded within communities, closer to patients’ homes, and provide ongoing patient management (Line 63).

Complexity: improving capacity at the clinic and community level

Similar to design quality and packaging, the complexity of providing TPT and reaching patients at the household-level came up often. For example, access to household contacts is difficult because the burden rests on patients (passive case finding) or strains the health system (Line 13). Once household contacts are identified, having a sensitive and specific algorithm for ruling out TB disease among different populations complicates screening and examinations of contacts. Participants felt it was important to understand who should do certain tasks (i.e., community health workers, nurses, doctors) for program success. Once patients initiate TPT, multifaceted challenges remain. In particular, ensuring patients stay engaged with care and adhere to TPT can be difficult (Line 16). The duration of the intervention (i.e., following each family for at least 12 months) and deciding which clinics and patients to prioritize were additional complexities discussed (Line 26).

Outer setting

Needs and resources of those served by the organization: high community needs and few resources

Many participants discussed the significant needs of the community pertaining to this TB program (Line 166). Some HCWs described the importance of providing community-based education via a TPT campaign ensuring community members understand what TPT is and why it is important (Line 165). Lack of transportation and prohibitive costs of transport were consistently mentioned (167, 168, 169). Additionally, getting TB-exposed community members to clinics was perceived as difficult for many HCWs (Line 174, 176).

Another theme within this domain was the discussion of perceived acceptability of patient engagement. For example, participants felt adolescents and men were hard groups to reach; however, elderly individuals may be easier to engage. Therefore, elders could be enablers and support other family members (Line 177). Other participants felt women and children would be easier to reach than men for TPT (Line 181).

Documentation for TPT was also noted as a resource barrier at both hospital and clinics (Line 183). Another barrier to success were stock outs of medications, particularly in clinics, most often reported by doctors and pharmacists (Line 186).

Inner setting

Readiness for implementation—available resources: nurses and community health workers need additional support and resources

Concepts that came up regarding the hospital and district’s readiness for implementation specific to available resources varied from easy to complex, including the need for better access to diagnostics. For example, one doctor said “Unfortunately, we don’t have 24-h lab services. So, if you see a patient after hours and you’re concerned about TB, unfortunately they'll have to sleep over [in the outpatient department] with other patients…which is quite a risk, but we can’t send them home because there's no transport and it’s quite far out for most of our patients” (Doctor, Male, Line 212).

Many HCWs discussed the need for resources to aid clinicians ruling out TB disease and prioritizing who receives TPT. Additionally, medical charts to document TPT prescriptions are absent. This lack of documentation infrastructure has been a reason why some HCWs believe TPT has never been prioritized or implemented effectively. The suggestion of algorithms for clinician utilization came up again (Line 218, 215, 219).

Implementation climate—relative priority: survival mode versus sustained momentum

Individuals described TB screening programs often lose priority because of the day-to-day “fires” many clinicians metaphorically put out (Line 98, 106, 108). Participants mentioned they often function in “survival mode” and adding another program may be too much (Line 99). A TPT program is seen as important until something like COVID comes along and derails momentum (Line 100). Also, some participants noted screening for TB can be overwhelming because it is too big of a problem to tackle (Line 104).

Additionally, the need to shift HCWs perspective on preventing drug-sensitive TB was a theme among some respondents. HIV is taken seriously and seen as a disease to prevent and treat, while TB is less clear. However, some HCWs viewed screening and close follow-up for TPT as feasible and especially urgent for drug-resistant TB (Line 112, 114).

Nevertheless, for the apathy some participants reported, multiple participants brought up the central role nurses should play in TPT delivery. Nurses were thought to be better suited to screen patients for TB than doctors (Line 83) and nurses could improve TB care through TPT if they were motivated, provided with appropriate training, had support from colleagues, and given time to provide patient education (Lines 234, 236, 238).

Readiness for implementation—access to knowledge and information: improved access to information is desperately needed

Access to knowledge and information about TPT and how to incorporate it into daily workflows was lacking for many HCWs. They discussed rarely learning about TPT in university and feeling unprepared to teach others about TPT when they had poor understanding themselves (Line 199, 198, 200). A pharmacist suggested how an online platform (Knowledge Hub) was used to quickly disseminate information about COVID-19, and a similar, platform could allow clinicians to access information about TPT too.

Implementation climate—learning climate: optimism about the future of TB care

The learning climate was one construct where optimism was most present. Many participants described their lack of training in TPT management, yet even with little previous training, there was great willingness to learn about TPT and the recognition for the continuous nature of learning needs (Line 89). Time constraints were palpable among clinicians; thus, providing short educational opportunities with limited disruption to their daily schedules is important (Line 98).

Characteristics of the individual

Knowledge and beliefs about the innovation: give us knowledge and we will disseminate

Participants’ positive attitudes toward, and value placed on, this innovation was commonly discussed. Specifically, many found it important to educate patients about TB, differentiate between TB infection and disease, and explain why TPT is crucial even when patients are not demonstrably sick (Line 160). Healthcare workers were keen to learn more about TPT and if given sufficient training and resources agreed that a systematic implementation approach is needed for success (Line 130, 133,135, 139, 142, 146).

Self-efficacy: in order not to make a mistake, let us not do anything

Self-efficacy, or an individual’s beliefs in their own capabilities to execute courses of action to achieve implementation goals, [11] varied between different types of HCWs. Some interviews centered around providers—mostly nurses—not wanting to “do anything wrong” and, therefore, defaulted to doing very little regarding TPT (Line 272, 274, 275).

Disempowerment and lack of clear TB and TPT policies have often led to suboptimal implementation (Line 277). Despite the lack of self-efficacy discussed, many participants stated nurses and clinics are better suited to lead TPT program implementation because nurses spend more time with patients than doctors, nurses are knowledgeable on current TPT regimens, and they are often more adherent to guidelines than other clinical cadres. Structurally, clinics (staffed by nurses) are also more accessible to patients (Line 281, 280, 279). Currently, nurses seem to be doing the bulk of work around TPT, so providing nurses leadership roles and resources necessary to lead TPT programs could improve its effectiveness (Line 284, 281).


Champions: necessary in the clinic and the community

Having champions—both HCW champions as well as community champions (i.e., grandmothers, elders, chiefs)—was discussed as an important puzzle piece to support TPT implementation. One individual said: “nurses are far better at screening than doctors and I know the way our system works here, an intentional TB screen is supposed to happen for every patient. And I think it does happen actually quite well because it's part of the triage process [in the outpatient department at the hospital].” (Doctor, Male, Line 83).

The description of nurses being well trained to follow and implement guidelines—when given the resources to do so, being respected and knowledgeable (Line 191), and having a program that is integrated into a triage process—helps ensure that it gets completed without adding too much additional strain to individuals or the organization. In addition to nurses as being potential champions to successfully launch a TPT program, elders were also thought to be potential champions.


There are multifaceted barriers to overcome prior to implementation of an effective TPT program in this setting such as optimal HCW knowledge around TPT, intervention design and packaging, and increased resources. However, leveraging facilitators such as positive HCW attitudes, existing partnerships and champions, and dedicated TB nursing staff may improve implementation and program sustainability. Improving HCW knowledge regarding efficacy of TPT is necessary prior to effective implementation of a TPT program, especially as new regimens such as shorter 3-month combinations of isoniazid and rifapentine (3HP) are becoming more widely available and recommended. An identified enabler was that HCWs have positive attitudes towards learning about TPT effectiveness and how to rule out TB. Providing systematic support through simple and clinically relevant documentation workflows could also enable successful program implementation. Therefore, providing education with high engagement, that is free to access repeatedly, and available at the point-of-care is ideal [14, 15]. Finally, ensuring the TB program is nurse-led and clinic-based is important for feasibility, cost, and scalability [16, 17]. In summary, participants were enthusiastic but felt the need for more knowledge, clear guidelines, specific workflows, and continuous momentum. Table 4 describes next steps for program implementation.

Table 4 Next steps

Central to any intervention is its design and packaging. Similar to other studies assessing TPT in the Eastern Cape [18,19,20], participants in this study reported lack of standard documentation for TPT to be one key barrier to implementation and critical to program design. Designing thoughtful and simple documentation systems is essential since often “what gets measured gets done” [21]. Ensuring the program is patient-centered and aligns with the WHO’s End TB Strategy Pillar One, which “puts patients at the heart of service delivery,” is also important [22]. Guaranteeing patient voices are heard and involved in the design of the program and provided options for TPT (when possible) is an important next step in this context.

Additionally, the availability and need for resources and competing priorities were common barriers discussed. Research in TB and primary care shows that nurses and non-physician clinicians are excellent at following clinical guidelines and they provide quality care in resource constrained settings [14, 23,24,25,26]. Additionally, care cascades for TB (similar to HIV 90–90-90 targets) have been difficult to utilize in this setting for numerous reasons such as lack of documentation for TPT, or unclear eligibility requirements, and thus inability to determine if a person should or should not be included in a “step” of a cascade, which participants discussed as a potential barrier [18,19,20]. However, cascade indicators are starting to be used in TB care more, though less in preventive therapy, potentially due to lack of quality reporting mechanisms [8, 27,28,29]. Ultimately, shifting the priority from a treatment-focused approach to prevention—in nursing and medical education, and in point-of-care algorithms and documentation systems—is necessary to transform comprehensive TB care. This is especially critical as South Africa has recently released updated guidelines greatly expanding TPT eligibility [30].


Interviews were conducted with a limited range of HCWs and limited scope of differing experiences. It would be prudent to further these data with community member and past or current patients with TB input. Finally, reliance on a pre-determined CFIR coding scheme could have led to authors missing pertinent data.


Healthcare workers need increased knowledge regarding TPT prior to implementing a comprehensive TB program, despite positive attitudes and beliefs about TPT. Furthermore, additional resources—time, trainings, and contextualized evidence—are needed to prescribe TPT more broadly. Tangible resources such as suitable documentation systems and funding to administer TPT programming are also critical to sustainability.

Availability of data and materials

The datasets analyzed during the current study are available from the corresponding author on reasonable request.





Tuberculosis preventive therapy


King Sabata Dalindyebo


Standards for reporting qualitative research


Consolidated framework for implementation research


Low- and middle-income countries


  1. Akolo C, Adetifa I, Shepperd S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2010;1:CD000171.

    Article  Google Scholar 

  2. Ayieko J, Abuogi L, Simchowitz B, Bukusi EA, Smith AH, Reingold A. Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta–analysis. BMC Infect Dis. 2014;14(1):91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Smieja MJ, Marchetti CA, Cook DJ, Smaill FM. Isoniazid for preventing tuberculosis in non-HIV infected persons. Cochrane Database Syst Rev. 2000;2:CD001363.

    Article  Google Scholar 

  4. Stagg HR, Zenner D, Harris RJ, Munoz L, Lipman MC, Abubakar I. Treatment of latent tuberculosis infection: a network meta-analysis. Ann Intern Med. 2014;161(6):419–28.

    Article  PubMed  Google Scholar 

  5. Hirsch-Moverman Y, Mantell JE, Lebelo L, et al. Provider attitudes about childhood tuberculosis prevention in Lesotho: a qualitative study. BMC Health Serv Res. 2020;20(1):461.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wambiya EOA, Atela M, Eboreime E, Ibisomi L. Factors affecting the acceptability of isoniazid preventive therapy among healthcare providers in selected HIV clinics in Nairobi County, Kenya: a qualitative study. BMJ Open. 2018;8(12):e024286.

    Article  PubMed  PubMed Central  Google Scholar 

  7. South African Department of Health. National Guidelines on the Treatment of Tuberculosis Infection. Pretoria. February 2023. 1-48.

  8. Baloyi DP, Anthony MG, Meyerson KA, et al. Reasons for poor uptake of TB preventive therapy in South Africa. Public Health Action. 2022;12(4):159–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Glasgow RE, Estabrooks PE. Pragmatic applications of RE-AIM for health care initiatives in community and clinical settings. Prev Chronic Dis. 2018;15:E02.

    Article  PubMed  PubMed Central  Google Scholar 

  10. South Africa National Department of Health. Let Our Actions Count: South Africa’s National Strategic Plan for HIV, TB and STIs 2017–2022.; 2017.

  11. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.

    Article  PubMed  PubMed Central  Google Scholar 

  12. O’Brien BC, Harris IB, Beckman TJ, Reed DA, Cook DA. Standards for reporting qualitative research: a synthesis of recommendations. Acad Med. 2014;89(9):1245.

    Article  PubMed  Google Scholar 

  13. Home | Dedoose. Accessed 24 Jan 2022. 

  14. Egger J, Gross J, Angwenyi P, et al. Evaluating the effects of organizational and educational interventions on adherence to clinical practice guidelines in a low resource primary care setting in Kenya. Presented at: Consortium of Universities for Global Health; March 26, 2015; Boston, MA.

  15. Bluestone J, Johnson P, Fullerton J, Carr C, Alderman J, BonTempo J. Effective in-service training design and delivery: evidence from an integrative literature review. Hum Resour Health. 2013;11:51.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Crowley T, Mokoka E, Geyer N. Ten years of nurse-initiated antiretroviral treatment in South Africa: a narrative review of enablers and barriers. South Afr J HIV Med. 2021;22(1):1196.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Loveday M, Wallengren K, Reddy T, et al. MDR-TB patients in KwaZulu-Natal, South Africa: cost-effectiveness of 5 models of care. PloS One. 2018;13(4):e0196003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. van de Water BJ, Meyer TN, Wilson M, Young C, Gaunt B, le Roux KW. TB prevention cascade at a district hospital in rural Eastern Cape, South Africa. Public Health Action. 2021;11(2):97–100.

    Article  PubMed  PubMed Central  Google Scholar 

  19. van de Water BJ, Vance AJ, Ramangoaela L, Botha M, Becerra MC. Prevention care cascade in people exposed to drug-resistant TB. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. 2020;24(12):1305–6.

    Article  Google Scholar 

  20. Black F, Amien F, Shea J. An assessment of the isoniazid preventive therapy programme for children in a busy primary healthcare clinic in Nelson Mandela Bay Health District, Eastern Cape Province. South Africa S Afr Med J. 2018;108(3):217–23.

    Article  CAS  PubMed  Google Scholar 

  21. UNAIDS. UNAIDS leads the world’s most extensive data collection on HIV epidemiology, programme coverage and finance. Published 2023. Accessed 4 May  2023.

  22. World Health Organization. A patient-centered approach to TB care. WHO/CDS/TB/201813. Published online 2018:2.

  23. Rosenberg K. Nurse-led intervention improves tuberculosis treatment completion in homeless population. AJN Am J Nurs. 2022;122(3):45.

    Article  PubMed  Google Scholar 

  24. Rao KD, Sundararaman T, Bhatnagar A, Gupta G, Kokho P, Jain K. Which doctor for primary health care? Quality of care and non-physician clinicians in India. Soc Sci Med. 1982;2013(84):30–4.

    Article  Google Scholar 

  25. Pai M, Temesgen Z. Quality: the missing ingredient in TB care and control. J Clin Tuberc Mycobact Dis. 2018;14:12–3.

    Article  Google Scholar 

  26. Kruk ME, Gage AD, Arsenault C, et al. High-quality health systems in the sustainable development goals era: time for a revolution. Lancet Glob Health. 2018;6(11):e1196–252.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Alsdurf H, Hill PC, Matteelli A, Getahun H, Menzies D. The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis. Lancet Infect Dis. 2016;16(11):1269–78.

    Article  PubMed  Google Scholar 

  28. Cazabon D, Alsdurf H, Satyanarayana S, et al. Quality of tuberculosis care in high burden countries: the urgent need to address gaps in the care cascade. Int J Infect Dis. 2017;56:111–6.

    Article  PubMed  Google Scholar 

  29. Subbaraman R, Nathavitharana RR, Mayer KH, et al. Constructing care cascades for active tuberculosis: a strategy for program monitoring and identifying gaps in quality of care. PLoS Med. 2019;16(2):e1002754.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Department of Health South Africa. Tuberculosis preventive therapy (TPT) in South Africa. Published online 2021.

Download references


We wholeheartedly thank the healthcare workers (i.e., participants) for their time, honestly, and willingness to discuss their experiences with us.


1K23NR019019-01A1 [BvdW]. The National Institute of Nursing Research had no role in the collection, analysis, or interpretation of data nor in writing the manuscript.

Author information

Authors and Affiliations



BvdW, KlR, BG, SG, and NW conceptualized the study; BvdW and MW were involved in the data acquisition and initial data analysis with further analysis and critique from KlR, BG, SG, and NW. BvdW drafted the manuscript with edits and final approval from all authors.

Corresponding author

Correspondence to Brittney J. van de Water.

Ethics declarations

Ethics approval and consent to participate

Ethics approval was obtained from the Harvard Medical School Institutional Review Board, Boston, MA, USA (IRB20-2122), and from Walter Sisulu University, Mthatha, Eastern Cape, South Africa (014/2021). Additionally, the Eastern Cape Department of Health also provided written approval for this study to take place in the Eastern Cape (EC_202104_002). Written informed consent was obtained from all participants.

Consent for publication

Not applicable.

Competing interests

Sarah Gimbel is a member of the Editorial Board for the journal. The authors declare that they have no other competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1:

Supplement 1. Healthcare worker interview guide on knowledge, attitudes, and beliefs regarding TB preventive therapy.

Additional file 2:

Supplement 2. Exemplar Quotes Per Consolidated Framework for Implementation Research Domains and Constructs.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

van de Water, B.J., Wilson, M., le Roux, K. et al. Healthcare worker perceived barriers and facilitators to implementing a tuberculosis preventive therapy program in rural South Africa: a content analysis using the consolidated framework for implementation research. Implement Sci Commun 4, 107 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: